SCRG1

Across TCGA patient cohorts, SCRG1 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCRG1-associated genes across cancer lineages are MIR4499, MIR4701, and MIR3193. Each is linked with SCRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCRG1-to-partner and partner-to-SCRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4499 grouped by SCRG1-low versus SCRG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCRG1→partner) and Y-score (partner→SCRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4499 →	+0.354	+3.344	.005	.007	3	1
UCEC	MIR4701 →	+1.098	+3.428	.001	.007	3	1
UCEC	MIR3193 →	+0.910	+2.838	<.001	.009	3	1
UCEC	IL21 →	+0.223	+2.763	<.001	.009	3	1
UCEC	DBF4P3 →	+0.044	+4.660	<.001	.003	3	1
UCEC	MIR219A1 →	+0.992	+3.477	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MIR4499 by SCRG1 expression — UCEC

Explore this box plot interactively →