SCRG1

Across TCGA pan-cancer cohorts, SCRG1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SCRG1 data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher SCRG1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCRG1 expression acts as an unfavorable survival marker, although some lineages such as DLBC and LAML show a favorable association.

UVM, KIRP, and BLCA are the cancer types where SCRG1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.419	0.743	<.001	147	view →
KIRP	OS	Median	All	0.573	0.774	<.001	83	view →
BLCA	DFS	Median	All	0.255	0.453	<.001	76	view →
OV	OS	Quartile	All	0.758	0.878	.004	56	view →
DLBC	OS	Median	IV	1.000	0.362	.003	52	view →
THYM	DFS	Quartile	All	0.495	0.904	.001	45	view →
READ	OS	Quartile	All	0.830	1.000	.002	38	view →
KICH	OS	Tertile	All	0.628	0.955	.007	36	view →
LAML	DFS	Quartile	All	0.530	0.235	.009	34	view →
COAD	DFS	Quartile	All	0.385	0.653	.006	21	view →
SARC	OS	Quartile	All	0.916	0.770	.003	15	view →
CHOL	DFS	Median	All	0.759	0.125	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SCRG1–UVM (DFS)

Open the UVM breakdown →