SCNN1D

Across TCGA patient cohorts, SCNN1D mutation is significantly associated with the RNA expression of many other genes, with 371 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCNN1D-associated genes across cancer lineages are MIR6780A, RNU7-28P, and MIR5088. Each is linked with SCNN1D in more than 2 cancer types. Because this analysis shows association rather than direction, both SCNN1D-to-partner and partner-to-SCNN1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6780A grouped by SCNN1D-low versus SCNN1D-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1D→partner) and Y-score (partner→SCNN1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR6780A →	+0.291	+3.542	.003	.007	3	3
BLCA	RNU7-28P →	+0.432	+3.479	<.001	.008	3	3
SKCM	MIR5088 →	+0.192	+4.634	<.001	.003	3	3
UCEC	C9orf62 →	+0.073	+3.041	.003	<.001	3	2
CESC	RNA5SP351 →	+0.209	+3.839	.003	.004	3	2
CESC	MIR4510 →	+0.195	+4.342	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 371 associations by consensus.

MIR6780A by SCNN1D expression — CESC

Explore this box plot interactively →