SCNN1D

Across TCGA pan-cancer cohorts, SCNN1D RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SCNN1D data layer compared with 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCNN1D RNA is associated with better overall survival. In most high-consensus cancer types, elevated SCNN1D expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

HNSC, KIRC, and KICH are the cancer types where SCNN1D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.771	0.601	<.001	124	view →
KIRC	DFS	Quartile	All	0.530	0.753	<.001	86	view →
KICH	DFS	Tertile	III,IV	0.033	1.000	.002	63	view →
COAD	OS	Tertile	All	0.727	0.871	.001	59	view →
PAAD	DFS	Tertile	All	0.593	0.366	<.001	39	view →
SKCM	OS	Quartile	II,III,IV	0.561	0.203	<.001	25	view →
OV	DFS	Median	IV	0.203	0.408	.001	24	view →
LUAD	DFS	Tertile	IV	0.487	0.909	.009	24	view →
ESCA	OS	Tertile	III,IV	0.699	0.349	.014	24	view →
PRAD	DFS	Median	All	0.675	0.904	<.001	18	view →
READ	DFS	Tertile	III,IV	0.685	0.213	.007	14	view →
ACC	OS	Tertile	II,III,IV	0.540	1.000	.021	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SCNN1D–HNSC (OS)

Open the HNSC breakdown →