SCNN1D

Across TCGA cell cohorts, SCNN1D mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCNN1D-associated genes across cancer lineages are OR6C70, ACTRT1, and C20orf85. Each is linked with SCNN1D in more than 1 cancer types. Because this analysis shows association rather than direction, both SCNN1D-to-partner and partner-to-SCNN1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C70 grouped by SCNN1D-low versus SCNN1D-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1D→partner) and Y-score (partner→SCNN1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR6C70 →	+0.066	+4.217	<.001	.001	3	2
BLOOD_Leukemia	ACTRT1 →	+0.014	+4.786	.004	<.001	3	1
BLOOD_Leukemia	C20orf85 →	+0.018	+4.384	.001	.006	3	1
BLOOD_Leukemia	KRT84 →	+0.437	+4.567	<.001	.001	3	1
BLOOD_Leukemia	SCGB3A2 →	+0.098	+4.507	<.001	.001	3	1
BLOOD_Leukemia	CST2 →	+0.397	+4.567	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

OR6C70 by SCNN1D expression — SKIN

Explore this box plot interactively →