SCNN1B

Across TCGA patient cohorts, SCNN1B protein abundance is significantly associated with the RNA expression of many other genes, with 1,201 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SCNN1B-associated genes across cancer lineages are CYTH4, ESS2, and SH3BP1. Each is linked with SCNN1B in more than 1 cancer types. Because this analysis shows association rather than direction, both SCNN1B-to-partner and partner-to-SCNN1B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCNN1B versus CYTH4 in LUAD, with a Pearson correlation of -0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1B→partner) and Y-score (partner→SCNN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CYTH4 →	-0.668	-0.673	.002	.001	3	1
LUAD	ESS2 →	-0.355	-0.854	.005	<.001	3	1
LUAD	SH3BP1 →	-0.466	-0.649	.003	.004	3	1
LUAD	LGALS1 →	-1.045	-0.845	<.001	.001	3	1
LUAD	DEPDC5 →	-0.297	-0.777	<.001	<.001	3	1
LUAD	HMOX1 →	-0.901	-0.681	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,201 associations by consensus.

SCNN1B vs CYTH4 — LUAD

Explore this scatter interactively →