SCNN1B

Across TCGA patient cohorts, SCNN1B mutation is significantly associated with the RNA expression of many other genes, with 2,417 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCNN1B-associated genes across cancer lineages are CDCA2, SKA1, and PBK. Each is linked with SCNN1B in more than 2 cancer types. Because this analysis shows association rather than direction, both SCNN1B-to-partner and partner-to-SCNN1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA2 grouped by SCNN1B-low versus SCNN1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1B→partner) and Y-score (partner→SCNN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA2 →	+0.831	+3.016	<.001	<.001	3	3
UCEC	SKA1 →	+0.680	+2.258	<.001	.001	3	3
UCEC	PBK →	+0.945	+3.700	<.001	.001	3	3
SKCM	NDUFA4P2 →	+0.047	+2.230	.006	.002	3	3
UCEC	RNA5SP411 →	+0.914	+2.015	<.001	.001	3	2
BRCA	OR5AM1P →	+0.056	+6.586	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,417 associations by consensus.

CDCA2 by SCNN1B expression — UCEC

Explore this box plot interactively →