SCNN1B

Across TCGA patient cohorts, SCNN1B mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCNN1B-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and PDCD4. Each is linked with SCNN1B in more than 2 cancer types. Because this analysis shows association rather than direction, both SCNN1B-to-partner and partner-to-SCNN1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SCNN1B-low versus SCNN1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1B→partner) and Y-score (partner→SCNN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.608	-2.584	<.001	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.569	+3.604	.012	.001	3	3
SKCM	PDCD4 →	-0.415	-2.115	.017	.018	3	2
UCEC	eIF4E →	+0.171	+2.820	.034	.035	3	2
UCEC	INPP4B →	-0.336	-3.700	.006	.001	3	2
UCEC	mTOR_pS2448 →	-0.127	-1.678	.026	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by SCNN1B expression — UCEC

Explore this box plot interactively →