SCNN1B

Across TCGA cell cohorts, SCNN1B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,952 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SCNN1B-associated GO terms across cancer lineages are Adenylate cyclase-modulating G protein-coupled receptor signaling pathway, Lysosomal lumen acidification, and Response to glucocorticoid. Each is linked with SCNN1B in more than 7 cancer types. Because this analysis shows association rather than direction, both SCNN1B-to-partner and partner-to-SCNN1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adenylate cyclase-modulating G protein-coupled receptor signaling pathway grouped by SCNN1B-low versus SCNN1B-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1B→partner) and Y-score (partner→SCNN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.057	-2.219	<.001	<.001	2	8
BREAST	Lysosomal lumen acidification →	+0.112	+1.848	.002	.004	3	6
UPPER_AERODIGESTIVE_TRACT	Response to glucocorticoid →	+0.071	+1.354	.001	.001	3	5
BREAST	Negative regulation of autophagy →	+0.047	+1.259	<.001	.001	3	5
LUNG_NSCLC_LUAD	RNA stabilization →	+0.057	+1.276	<.001	<.001	3	5
BLOOD_Lymphoma	Negative regulation of autophagosome maturation →	+0.076	+0.566	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,952 associations by consensus.

Adenylate cyclase-modulating G protein-coupled receptor signaling pathway by SCNN1B expression — BREAST

Explore this box plot interactively →