SCNN1A

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SCNN1A protein abundance is significantly associated with the RNA expression of many other genes, with 1,441 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SCNN1A-associated genes across cancer lineages are UBE2L2, EPAS1, and CEACAM3. Each is linked with SCNN1A in more than 1 cancer types. Because this analysis shows association rather than direction, both SCNN1A-to-partner and partner-to-SCNN1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCNN1A versus UBE2L2 in LUAD, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1A→partner) and Y-score (partner→SCNN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADUBE2L2 →+1.682+0.943.001.00132
LSCCEPAS1 →+1.198+1.693<.001<.00132
LSCCCEACAM3 →+1.163+1.608.001<.00132
LSCCBASP1 →+1.364+1.601<.001.00132
LUADPAPPA →+1.643+1.050.002.00132
LSCCADGRG3 →+1.553+1.740.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,441 associations by consensus.

SCNN1A vs UBE2L2 — LUAD

Per-sample scatter of SCNN1A vs UBE2L2 in LUAD (Pearson r = 0.47).

Explore this scatter interactively →

Exploration