SCNN1A

Across TCGA patient cohorts, SCNN1A mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCNN1A-associated genes across cancer lineages are EGFR_pY1068, Rad50, and Shc_pY317. Each is linked with SCNN1A in more than 1 cancer types. Because this analysis shows association rather than direction, both SCNN1A-to-partner and partner-to-SCNN1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SCNN1A-low versus SCNN1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1A→partner) and Y-score (partner→SCNN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.301	-3.807	.007	<.001	3	2
UCEC	Rad50 →	-0.248	-2.000	.023	.032	3	2
UCEC	Shc_pY317 →	-0.178	-2.321	.009	.034	3	2
UCEC	ASNS →	+0.530	+3.169	.001	.018	3	2
UCEC	C-Raf →	+0.259	+3.321	<.001	.010	3	2
UCEC	Di-Ras3 →	-0.170	-2.986	.011	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1068 by SCNN1A expression — UCEC

Explore this box plot interactively →