SCNN1A

Across TCGA cell cohorts, SCNN1A mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SCNN1A-associated genes across cancer lineages are LILRA1, KCNA5, and PRAMEF10. Each is linked with SCNN1A in more than 1 cancer types. Because this analysis shows association rather than direction, both SCNN1A-to-partner and partner-to-SCNN1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LILRA1 grouped by SCNN1A-low versus SCNN1A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1A→partner) and Y-score (partner→SCNN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LILRA1 →	+0.113	+4.930	<.001	.008	3	1
SOFT_TISSUE	KCNA5 →	+0.122	+5.369	<.001	.004	3	1
SOFT_TISSUE	PRAMEF10 →	+0.012	+4.930	.008	.008	3	1
SOFT_TISSUE	CT45A6 →	+0.022	+5.369	<.001	.004	3	1
CNS	OR11H6 →	+0.035	+5.321	<.001	.005	3	1
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

LILRA1 by SCNN1A expression — SOFT_TISSUE

Explore this box plot interactively →