SCN7A

Across TCGA patient cohorts, SCN7A protein abundance is significantly associated with the RNA expression of many other genes, with 10,218 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SCN7A-associated genes across cancer lineages are RAMP1, TMEM252, and GPX3. Each is linked with SCN7A in more than 2 cancer types. Because this analysis shows association rather than direction, both SCN7A-to-partner and partner-to-SCN7A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCN7A versus RAMP1 in COAD, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN7A→partner) and Y-score (partner→SCN7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAMP1 →	+1.125	+0.418	.003	.001	3	3
LUAD	TMEM252 →	+0.363	+0.480	.001	<.001	3	3
LSCC	GPX3 →	+0.838	+0.368	<.001	<.001	3	3
COAD	CHRDL1 →	+1.195	+0.445	.002	.001	3	3
GBM	SRPX →	+0.967	+0.526	.006	.005	3	3
LSCC	RGCC →	+0.712	+0.453	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,218 associations by consensus.

SCN7A vs RAMP1 — COAD

Explore this scatter interactively →