SCN7A

Across TCGA pan-cancer cohorts, SCN7A RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SCN7A data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SCN7A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SCN7A expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

LUAD, OV, and BLCA are the cancer types where SCN7A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.734	0.572	.001	75	view →
OV	OS	Tertile	IV	0.261	0.548	.003	64	view →
BLCA	OS	Median	II,III,IV	0.326	0.535	<.001	61	view →
LUSC	DFS	Median	II,III,IV	0.239	0.497	<.001	45	view →
BRCA	OS	Median	III,IV	0.664	0.387	<.001	44	view →
LGG	DFS	Tertile	All	0.388	0.561	<.001	42	view →
UVM	DFS	Tertile	All	0.459	0.887	.001	41	view →
MESO	OS	Tertile	All	0.543	0.277	.001	28	view →
PRAD	OS	Median	All	1.000	0.976	.010	16	view →
DLBC	OS	Median	All	0.222	1.000	.005	16	view →
SCLC	OS	Median	All	0.238	0.510	.015	13	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SCN7A–LUAD (DFS)

Open the LUAD breakdown →