SCN7A

Across TCGA pan-cancer cohorts, SCN7A RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SCN7A’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SCN7A RNA is repressed in tumor relative to normal tissue. In most cancer types SCN7A is over-expressed in tumor, although a few such as BLCA and KIRC show the opposite, repressed pattern.

BLCA, KIRC, and LUAD are the cancer types where SCN7A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCN7A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.077	<.001	12	view →
KIRC	Female	II,III,IV	−1.239	<.001	12	view →
LUAD	Female	III,IV	−3.160	<.001	11	view →
COAD	Male	II,III,IV	−2.715	<.001	11	view →
KIRP	Female	II,III,IV	−1.658	<.001	11	view →
LUSC	Female	II,III,IV	−4.237	<.001	9	view →
KICH	Male	II,III,IV	−1.103	<.001	9	view →
HNSC	Male	All	−0.736	<.001	8	view →
THCA	Female	III,IV	−0.582	.001	8	view →
READ	All	All	−3.645	<.001	7	view →
STAD	All	All	−1.722	<.001	7	view →
UCEC	All	All	−2.945	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SCN7A–BLCA

Open the BLCA breakdown →