SCN7A

Across TCGA patient cohorts, SCN7A mutation is significantly associated with the RNA expression of many other genes, with 5,894 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN7A-associated genes across cancer lineages are FAM72B, CDKN3, and SKA1. Each is linked with SCN7A in more than 4 cancer types. Because this analysis shows association rather than direction, both SCN7A-to-partner and partner-to-SCN7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM72B grouped by SCN7A-low versus SCN7A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN7A→partner) and Y-score (partner→SCN7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FAM72B →	+0.627	+3.356	<.001	.004	3	5
UCEC	CDKN3 →	+0.585	+1.711	<.001	<.001	3	5
UCEC	SKA1 →	+0.618	+1.558	<.001	<.001	3	5
LUAD	UBE2T →	+0.811	+2.819	.004	.001	3	4
UCEC	POLE2 →	+0.387	+1.423	.001	<.001	3	4
UCEC	PRPS2 →	+0.360	+2.021	.008	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,894 associations by consensus.

FAM72B by SCN7A expression — LUAD

Explore this box plot interactively →