SCN7A

Across TCGA patient cohorts, SCN7A mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN7A-associated genes across cancer lineages are Caveolin-1, ATM, and A-Raf_pS299. Each is linked with SCN7A in more than 4 cancer types. Because this analysis shows association rather than direction, both SCN7A-to-partner and partner-to-SCN7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by SCN7A-low versus SCN7A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN7A→partner) and Y-score (partner→SCN7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caveolin-1 →	-0.779	-3.169	.036	.019	3	5
UCEC	ATM →	-0.403	-1.253	.001	.006	3	4
LUSC	A-Raf_pS299 →	-0.194	-2.106	.049	.018	3	3
SKCM	Smad4 →	+0.067	+1.050	.030	.021	3	3
UCEC	eIF4E →	+0.193	+1.959	<.001	<.001	3	3
UCEC	Rad50 →	-0.161	-1.099	.014	.016	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Caveolin-1 by SCN7A expression — STAD

Explore this box plot interactively →