SCN7A

Across TCGA cell cohorts, SCN7A RNA expression is significantly associated with the go_rna of many other GO terms, with 376 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SCN7A-associated GO terms across cancer lineages are Amino acid transport, Negative regulation of vesicle fusion, and Negative regulation of calcium ion import into sarcoplasmic reticulum. Each is linked with SCN7A in more than 3 cancer types. Because this analysis shows association rather than direction, both SCN7A-to-partner and partner-to-SCN7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Amino acid transport grouped by SCN7A-low versus SCN7A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN7A→partner) and Y-score (partner→SCN7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Amino acid transport →	-0.051	-0.019	.001	.008	3	4
SKIN	Negative regulation of vesicle fusion →	-0.323	-0.042	.001	.003	3	3
SOFT_TISSUE	Negative regulation of calcium ion import into sarcoplasmic reticulum →	+0.870	+0.438	.001	.005	3	3
SKIN	Glucosamine metabolic process →	+0.093	+0.047	<.001	.006	3	3
CNS	Sphingolipid mediated signaling pathway →	-0.067	-0.029	.001	.004	3	2
CNS	Regulation of myoblast differentiation →	-0.062	-0.029	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 376 associations by consensus.

Amino acid transport by SCN7A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →