SCN7A

Across TCGA cell cohorts, SCN7A mutation is significantly associated with the RNA expression of many other genes, with 569 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN7A-associated genes across cancer lineages are ZNF484, ARPP19, and CAPN7. Each is linked with SCN7A in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN7A-to-partner and partner-to-SCN7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF484 grouped by SCN7A-low versus SCN7A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN7A→partner) and Y-score (partner→SCN7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF484 →	+0.505	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	ARPP19 →	+0.478	+1.850	.002	.006	3	2
LARGE_INTESTINE	CAPN7 →	+0.516	+2.184	<.001	.003	3	2
LARGE_INTESTINE	RBSN →	+0.478	+2.364	.001	<.001	3	2
LARGE_INTESTINE	DOCK5 →	+0.732	+1.936	.005	.005	3	2
LARGE_INTESTINE	C21orf91 →	+0.590	+2.023	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 569 associations by consensus.

ZNF484 by SCN7A expression — LARGE_INTESTINE

Explore this box plot interactively →