SCN4A

Across TCGA patient cohorts, SCN4A protein abundance is significantly associated with the RNA expression of many other genes, with 9,462 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SCN4A-associated genes across cancer lineages are RHBG, DLX1, and ACAD8. Each is linked with SCN4A in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN4A-to-partner and partner-to-SCN4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCN4A versus RHBG in HNSC, with a Pearson correlation of -0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN4A→partner) and Y-score (partner→SCN4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RHBG →	-0.752	-0.573	<.001	.004	3	1
HNSC	DLX1 →	-1.226	-0.573	.001	.004	3	1
HNSC	ACAD8 →	-0.776	-0.573	.004	.004	3	1
HNSC	TMEM126A →	-0.836	-0.573	.005	.004	3	1
HNSC	GATA2 →	-1.642	-0.573	.005	.004	3	1
HNSC	RN7SKP170 →	+0.707	+0.573	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,462 associations by consensus.

SCN4A vs RHBG — HNSC

Explore this scatter interactively →