SCN4A

Across TCGA pan-cancer cohorts, SCN4A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SCN4A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SCN4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SCN4A is over-expressed in tumor, although a few such as KIRP and HNSC show the opposite, repressed pattern.

KIRC, LIHC, and KIRP are the cancer types where SCN4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCN4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.190	<.001	11	view →
LIHC	All	III,IV	+0.606	<.001	9	view →
KIRP	Male	All	−0.524	<.001	9	view →
HNSC	Male	All	−1.366	.004	8	view →
BRCA	All	III,IV	−2.054	<.001	6	view →
KICH	All	All	−0.525	<.001	5	view →
COAD	All	All	−0.187	.007	5	view →
LUAD	All	All	+0.350	<.001	4	view →
READ	All	All	−0.588	.005	2	view →
BLCA	Male	IV	−0.420	<.001	2	view →
PRAD	All	All	−0.199	.007	2	view →
THCA	Male	III,IV	−1.177	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SCN4A–KIRC

Open the KIRC breakdown →