SCN4A

Across TCGA pan-cancer cohorts, SCN4A RNA is linked to patient survival in 31 of 34 cancer types, making it the most broadly survival-associated SCN4A data layer compared with 9 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SCN4A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SCN4A expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUAD show a favorable association.

KIRC, UVM, and UCEC are the cancer types where SCN4A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.712	0.543	<.001	120	view →
UVM	DFS	Quartile	II,III,IV	0.315	0.771	<.001	89	view →
UCEC	DFS	Quartile	All	0.790	0.909	.001	36	view →
LUAD	OS	Tertile	III,IV	0.752	0.556	.004	36	view →
LIHC	OS	Tertile	All	0.553	0.397	.005	35	view →
COAD	OS	Tertile	II,III,IV	0.776	0.935	.005	34	view →
BRCA	OS	Tertile	III,IV	0.903	0.729	.001	31	view →
UCS	DFS	Median	II,III,IV	0.531	0.156	.007	30	view →
LGG	DFS	Quartile	All	0.691	0.880	<.001	30	view →
OV	OS	Quartile	All	0.771	0.915	.002	28	view →
HNSC	OS	Tertile	All	0.651	0.781	.006	23	view →
MESO	OS	Quartile	All	0.212	0.808	.006	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 31 lineages.

SCN4A–KIRC (DFS)

Open the KIRC breakdown →