SCN4A

Across TCGA patient cohorts, SCN4A protein abundance is significantly associated with the protein abundance of many other proteins, with 22,121 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SCN4A-associated proteins across cancer lineages are MINDY4_S524, MRRF, and CTU2. Each is linked with SCN4A in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN4A-to-partner and partner-to-SCN4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCN4A versus MINDY4_S524 in HNSC, with a Pearson correlation of 0.83.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN4A→partner) and Y-score (partner→SCN4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MINDY4_S524 →	+0.963	+0.573	.001	.004	3	1
HNSC	MRRF →	-0.916	-0.780	.002	.003	3	1
HNSC	CTU2 →	-0.460	-0.819	<.001	.002	3	1
HNSC	AHCTF1_S1944 →	+0.526	+0.780	<.001	.004	3	1
HNSC	ENO1_S157 →	-0.806	-0.780	.001	.003	3	1
HNSC	WAPL_S77 →	-0.653	-0.753	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,121 associations by consensus.

SCN4A vs MINDY4_S524 — HNSC

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