SCN4A

Across TCGA patient cohorts, SCN4A mutation is significantly associated with the total protein of many other genes, with 95 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN4A-associated genes across cancer lineages are Cyclin-B1, Chk1, and GAPDH. Each is linked with SCN4A in more than 3 cancer types. Because this analysis shows association rather than direction, both SCN4A-to-partner and partner-to-SCN4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SCN4A-low versus SCN4A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN4A→partner) and Y-score (partner→SCN4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-B1 →	+0.479	+2.700	.010	.005	3	4
LUAD	Chk1 →	+0.360	+2.459	<.001	.018	3	4
COAD	GAPDH →	+0.486	+1.774	.004	.008	3	4
UCEC	ASNS →	+0.178	+1.241	.041	.012	3	4
UCEC	ATM →	-0.530	-1.652	<.001	<.001	3	4
STAD	Rictor_pT1135 →	-0.175	-2.700	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

Cyclin-B1 by SCN4A expression — STAD

Explore this box plot interactively →