SCN4A

Across TCGA cell cohorts, SCN4A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,058 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SCN4A-associated GO terms across cancer lineages are Positive regulation of DNA repair, Symbiont-mediated disruption of host cell PML body, and Positive regulation of double-strand break repair via homologous recombination. Each is linked with SCN4A in more than 6 cancer types. Because this analysis shows association rather than direction, both SCN4A-to-partner and partner-to-SCN4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by SCN4A-low versus SCN4A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN4A→partner) and Y-score (partner→SCN4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of DNA repair →	+0.076	+0.650	<.001	.006	3	7
LUNG_NSCLC_LUAD	Symbiont-mediated disruption of host cell PML body →	+0.071	+0.141	.002	.006	3	6
BONE	Positive regulation of double-strand break repair via homologous recombination →	+0.083	+0.578	<.001	.001	3	6
BLOOD_Lymphoma	B cell proliferation involved in immune response →	+1.775	+0.944	<.001	<.001	3	6
BLOOD_Lymphoma	Negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains →	-0.094	-1.132	<.001	<.001	3	6
BLOOD_Lymphoma	GMP metabolic process →	+0.081	+1.001	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,058 associations by consensus.

Positive regulation of DNA repair by SCN4A expression — BONE

Explore this box plot interactively →