SCN4A

Across TCGA cell cohorts, SCN4A mutation is significantly associated with the RNA expression of many other genes, with 830 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN4A-associated genes across cancer lineages are RIC8B, CFHR2, and EHBP1. Each is linked with SCN4A in more than 3 cancer types. Because this analysis shows association rather than direction, both SCN4A-to-partner and partner-to-SCN4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIC8B grouped by SCN4A-low versus SCN4A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN4A→partner) and Y-score (partner→SCN4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RIC8B →	+0.445	+2.949	.003	<.001	3	4
BLOOD_Leukemia	CFHR2 →	+0.111	+3.124	<.001	.004	3	3
LUNG_NSCLC_LUAD	EHBP1 →	+0.610	+2.437	.003	.007	3	2
LUNG_NSCLC_LUAD	ISG15 →	-1.493	-2.663	.001	.003	3	2
LUNG_NSCLC_LUAD	CFHR1 →	+0.889	+2.479	<.001	.001	3	2
OVARY	C12orf40 →	+0.010	+4.444	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 830 associations by consensus.

RIC8B by SCN4A expression — LARGE_INTESTINE

Explore this box plot interactively →