SCN3B

Across TCGA patient cohorts, SCN3B mutation is significantly associated with the RNA expression of many other genes, with 1,883 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN3B-associated genes across cancer lineages are FREM2-AS1, NOL12, and DNM1P28. Each is linked with SCN3B in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN3B-to-partner and partner-to-SCN3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FREM2-AS1 grouped by SCN3B-low versus SCN3B-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN3B→partner) and Y-score (partner→SCN3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	FREM2-AS1 →	+0.542	+5.421	<.001	.005	3	2
UCEC	NOL12 →	+0.352	+3.617	<.001	.001	3	2
SKCM	DNM1P28 →	+0.056	+2.765	<.001	.004	3	2
SKCM	CRYBB2P1 →	+0.534	+3.372	<.001	.004	3	2
SKCM	DDX11 →	+0.493	+3.839	.007	<.001	3	2
UCEC	ULK3 →	+0.507	+2.254	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,883 associations by consensus.

FREM2-AS1 by SCN3B expression — READ

Explore this box plot interactively →