SCN3B

Across TCGA pan-cancer cohorts, SCN3B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SCN3B’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SCN3B RNA is repressed in tumor relative to normal tissue. In most cancer types SCN3B is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and UCEC are the cancer types where SCN3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCN3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.557	<.001	11	view →
COAD	Male	All	−0.560	<.001	11	view →
UCEC	All	All	−1.293	<.001	8	view →
BRCA	Female	II,III,IV	−1.099	<.001	6	view →
KICH	Male	All	−0.680	<.001	6	view →
LUSC	Female	II,III,IV	−0.550	.007	4	view →
LUAD	Female	All	−0.389	<.001	4	view →
READ	Female	All	−1.008	<.001	3	view →
BLCA	All	IV	−0.667	.010	2	view →
CHOL	All	All	+0.568	<.001	2	view →
PRAD	All	All	−0.248	.002	2	view →
KIRP	Female	All	+0.871	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SCN3B–THCA

Open the THCA breakdown →