SCN2B

Across TCGA patient cohorts, SCN2B mutation is significantly associated with the RNA expression of many other genes, with 1,767 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN2B-associated genes across cancer lineages are SNORD30, SENP3-EIF4A1, and LINC02038. Each is linked with SCN2B in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN2B-to-partner and partner-to-SCN2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD30 grouped by SCN2B-low versus SCN2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN2B→partner) and Y-score (partner→SCN2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD30 →	+0.965	+3.258	<.001	<.001	3	2
UCEC	SENP3-EIF4A1 →	+0.170	+2.684	<.001	.004	3	2
UCEC	LINC02038 →	+0.512	+2.617	.001	<.001	3	2
SKCM	MTCYBP10 →	+0.026	+4.408	<.001	.005	3	2
UCEC	LIN7C →	+0.547	+2.593	.003	.006	3	1
UCEC	COX15 →	+0.526	+2.914	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,767 associations by consensus.

SNORD30 by SCN2B expression — UCEC

Explore this box plot interactively →