SCN2B

Across TCGA cell cohorts, SCN2B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN2B-associated genes across cancer lineages are VN1R4, ZNF831, and TAFA1. Each is linked with SCN2B in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN2B-to-partner and partner-to-SCN2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R4 grouped by SCN2B-low versus SCN2B-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN2B→partner) and Y-score (partner→SCN2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CENPVL1 →	+0.227	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

VN1R4 by SCN2B expression — CNS

Explore this box plot interactively →