SCN11A

Across TCGA patient cohorts, SCN11A mutation is significantly associated with the RNA expression of many other genes, with 5,232 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN11A-associated genes across cancer lineages are POLE2, CDC20, and RFC4. Each is linked with SCN11A in more than 4 cancer types. Because this analysis shows association rather than direction, both SCN11A-to-partner and partner-to-SCN11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE2 grouped by SCN11A-low versus SCN11A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN11A→partner) and Y-score (partner→SCN11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	POLE2 →	+0.713	+2.819	<.001	.001	3	5
STAD	CDC20 →	+0.863	+2.906	.001	.001	3	5
LUAD	RFC4 →	+0.653	+1.859	<.001	.005	3	5
STAD	CKS1B →	+0.669	+3.622	<.001	.001	3	5
UCEC	EME1 →	+0.389	+1.461	.001	<.001	3	5
STAD	CCNB2 →	+0.776	+2.923	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,232 associations by consensus.

POLE2 by SCN11A expression — LUAD

Explore this box plot interactively →