SCN11A

Across TCGA pan-cancer cohorts, SCN11A RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SCN11A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SCN11A RNA is repressed in tumor relative to normal tissue. In most cancer types SCN11A is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and KICH are the cancer types where SCN11A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCN11A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.694	<.001	12	view →
KIRC	Female	All	−0.220	<.001	11	view →
KICH	Male	All	−0.536	<.001	10	view →
LUAD	Female	II,III,IV	−0.222	<.001	10	view →
HNSC	All	III,IV	−0.179	.001	10	view →
THCA	Male	All	−0.220	<.001	9	view →
UCEC	All	All	−0.242	<.001	8	view →
BRCA	All	III,IV	−0.709	<.001	6	view →
KIRP	Male	All	−0.259	<.001	6	view →
BLCA	Male	All	−1.766	.022	4	view →
LUSC	Male	II,III,IV	−0.219	<.001	4	view →
READ	All	All	−0.753	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SCN11A–COAD

Open the COAD breakdown →