SCN11A

Across TCGA cell cohorts, SCN11A mutation is significantly associated with the RNA expression of many other genes, with 180 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN11A-associated genes across cancer lineages are PIGY, SLAMF8, and MC2R. Each is linked with SCN11A in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN11A-to-partner and partner-to-SCN11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIGY grouped by SCN11A-low versus SCN11A-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN11A→partner) and Y-score (partner→SCN11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PIGY →	+1.158	+4.108	.008	.005	3	2
LUNG_SCLC	SLAMF8 →	+0.520	+3.111	.001	.009	3	2
STOMACH	MC2R →	+0.004	+3.209	<.001	.007	3	2
BLOOD_Leukemia	USP17L3 →	+0.016	+3.922	<.001	.002	3	2
BLOOD_Leukemia	C3orf85 →	+0.036	+4.539	<.001	<.001	3	2
LARGE_INTESTINE	STK32C →	+0.709	+3.169	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 180 associations by consensus.

PIGY by SCN11A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →