SCML1

Across TCGA patient cohorts, SCML1 mutation is significantly associated with the RNA expression of many other genes, with 1,271 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCML1-associated genes across cancer lineages are RNU6-206P, RNU6-210P, and RN7SL248P. Each is linked with SCML1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCML1-to-partner and partner-to-SCML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-206P grouped by SCML1-low versus SCML1-high in KIRC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCML1→partner) and Y-score (partner→SCML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	RNU6-206P →	+0.248	+5.652	.003	.004	3	2
KIRC	RNU6-210P →	+0.290	+7.203	<.001	<.001	3	2
UCEC	RN7SL248P →	+0.062	+3.219	<.001	.004	3	2
KIRC	OR2M5 →	+0.030	+5.985	.009	.002	3	1
KIRC	RNU6-1172P →	+0.257	+6.540	<.001	.001	3	1
KIRC	RN7SKP81 →	+0.092	+6.412	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,271 associations by consensus.

RNU6-206P by SCML1 expression — KIRC

Explore this box plot interactively →