SCML1

Across TCGA pan-cancer cohorts, SCML1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SCML1 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SCML1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCML1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

KIRP, ACC, and LGG are the cancer types where SCML1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.341	0.698	<.001	90	view →
ACC	DFS	Tertile	All	0.230	0.746	<.001	41	view →
LGG	OS	Median	All	0.743	0.875	<.001	40	view →
LIHC	DFS	Quartile	All	0.423	0.619	<.001	33	view →
SKCM	OS	Tertile	III,IV	0.516	0.217	.001	32	view →
KICH	OS	Median	III,IV	0.556	1.000	.010	32	view →
KIRC	DFS	Quartile	II,III,IV	0.413	0.754	.004	20	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	15	view →
MESO	DFS	Median	IV	0.184	0.440	.010	15	view →
UVM	DFS	Tertile	All	0.544	1.000	.011	14	view →
ESCA	OS	Median	All	0.449	1.000	.011	14	view →
PRAD	DFS	Median	All	0.755	0.812	.018	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SCML1–KIRP (DFS)

Open the KIRP breakdown →