SCIN

Across TCGA patient cohorts, SCIN protein abundance is significantly associated with the RNA expression of many other genes, with 18,849 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SCIN-associated genes across cancer lineages are TTPAL, VAV1, and PLAC8. Each is linked with SCIN in more than 3 cancer types. Because this analysis shows association rather than direction, both SCIN-to-partner and partner-to-SCIN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCIN versus TTPAL in COAD, with a Pearson correlation of -0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCIN→partner) and Y-score (partner→SCIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TTPAL →	-0.687	-0.456	<.001	<.001	3	4
GBM	VAV1 →	+0.990	+1.376	<.001	<.001	3	4
HNSC	PLAC8 →	+0.977	+0.439	<.001	<.001	3	4
GBM	MEX3A →	-1.087	-0.809	<.001	<.001	3	4
GBM	TMEM176A →	+0.878	+0.808	<.001	<.001	3	4
GBM	TBXAS1 →	+0.873	+1.274	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,849 associations by consensus.

SCIN vs TTPAL — COAD

Explore this scatter interactively →