SCIN

Across TCGA pan-cancer cohorts, SCIN RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SCIN data layer compared with 8 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher SCIN RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SCIN expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRC show a favorable association.

MESO, KIRC, and LGG are the cancer types where SCIN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.490	0.286	.003	81	view →
KIRC	OS	Tertile	II,III,IV	0.771	0.625	.005	53	view →
LGG	OS	Median	All	0.386	0.502	<.001	51	view →
LIHC	OS	Tertile	All	0.430	0.624	<.001	48	view →
ESCA	DFS	Median	All	0.413	0.878	.005	27	view →
KIRP	OS	Tertile	All	0.974	0.882	.006	27	view →
UCEC	OS	Tertile	IV	0.573	0.867	.020	14	view →
PRAD	DFS	Quartile	All	0.961	0.876	.022	14	view →
CESC	DFS	Tertile	IV	0.070	0.557	.021	12	view →
LUSC	DFS	Median	All	0.789	0.704	.027	6	view →
THCA	OS	Median	IV	0.562	0.914	.031	5	view →
ACC	DFS	Quartile	All	0.201	0.630	.013	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SCIN–MESO (DFS)

Open the MESO breakdown →