SCIN

Across TCGA pan-cancer cohorts, SCIN RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SCIN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SCIN RNA is repressed in tumor relative to normal tissue. In most cancer types SCIN is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where SCIN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCIN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−4.028	<.001	12	view →
HNSC	Male	III,IV	−1.771	<.001	12	view →
COAD	Female	All	−2.900	<.001	11	view →
LIHC	Female	All	+0.177	<.001	8	view →
READ	All	II,III,IV	−2.067	<.001	7	view →
LUSC	Female	II,III,IV	−1.205	<.001	5	view →
STAD	All	II,III,IV	−1.155	.003	5	view →
PAAD	Male	All	+1.370	.013	4	view →
LUAD	Female	All	+0.698	.008	3	view →
BRCA	Female	All	+0.365	.011	3	view →
KIRP	Female	II,III,IV	+0.897	.039	2	view →
CHOL	All	All	+0.877	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SCIN–KIRC

Open the KIRC breakdown →