SCIN

Across TCGA patient cohorts, SCIN mutation is significantly associated with the RNA expression of many other genes, with 3,401 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCIN-associated genes across cancer lineages are CHEK1, DONSON, and LZIC. Each is linked with SCIN in more than 2 cancer types. Because this analysis shows association rather than direction, both SCIN-to-partner and partner-to-SCIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK1 grouped by SCIN-low versus SCIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCIN→partner) and Y-score (partner→SCIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHEK1 →	+0.626	+4.191	<.001	<.001	3	3
UCEC	DONSON →	+0.387	+1.856	.003	.004	3	3
UCEC	LZIC →	+0.584	+2.496	<.001	<.001	3	3
UCEC	CHCHD4 →	+0.370	+2.959	<.001	<.001	3	3
UCEC	GNL3 →	+0.466	+3.130	<.001	<.001	3	3
UCEC	SLBP →	+0.510	+4.119	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,401 associations by consensus.

CHEK1 by SCIN expression — UCEC

Explore this box plot interactively →