SCIN

Across TCGA patient cohorts, SCIN mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCIN-associated genes across cancer lineages are ATM, eEF2, and eIF4E. Each is linked with SCIN in more than 2 cancer types. Because this analysis shows association rather than direction, both SCIN-to-partner and partner-to-SCIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SCIN-low versus SCIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCIN→partner) and Y-score (partner→SCIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.531	-1.874	<.001	.002	3	3
UCEC	eEF2 →	+0.258	+1.321	.031	.029	3	2
UCEC	eIF4E →	+0.202	+2.201	.004	<.001	3	2
UCEC	MEK1 →	+0.424	+2.201	<.001	<.001	3	2
UCEC	TFRC →	+0.556	+2.807	.001	.002	3	2
UCEC	EGFR →	-0.166	-1.807	.001	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ATM by SCIN expression — UCEC

Explore this box plot interactively →