SCIN

Across TCGA cell cohorts, SCIN RNA expression is significantly associated with the go_rna of many other GO terms, with 2,296 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SCIN-associated GO terms across cancer lineages are Protein transport within lipid bilayer, Serotonin secretion, and Serotonin production involved in inflammatory response. Each is linked with SCIN in more than 7 cancer types. Because this analysis shows association rather than direction, both SCIN-to-partner and partner-to-SCIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein transport within lipid bilayer grouped by SCIN-low versus SCIN-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCIN→partner) and Y-score (partner→SCIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein transport within lipid bilayer →	+0.894	+0.879	.004	.008	3	8
LUNG_SCLC	Serotonin secretion →	+1.505	+2.994	<.001	<.001	3	7
LUNG_SCLC	Serotonin production involved in inflammatory response →	+1.505	+2.994	<.001	<.001	3	7
LUNG_SCLC	Serotonin secretion involved in inflammatory response →	+1.505	+2.994	<.001	<.001	3	7
BONE	Protein transport into membrane raft →	+0.822	+0.716	.004	.007	3	7
STOMACH	Negative regulation of CD8-positive, alpha-beta T cell differentiation →	+0.204	+2.287	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,296 associations by consensus.

Protein transport within lipid bilayer by SCIN expression — BONE

Explore this box plot interactively →