SCIN

Across TCGA cell cohorts, SCIN mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCIN-associated genes across cancer lineages are UGT2B11, UGT2B10, and IFNG. Each is linked with SCIN in more than 1 cancer types. Because this analysis shows association rather than direction, both SCIN-to-partner and partner-to-SCIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UGT2B11 grouped by SCIN-low versus SCIN-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCIN→partner) and Y-score (partner→SCIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UGT2B11 →	+0.033	+4.643	<.001	.003	3	2
BREAST	UGT2B10 →	+0.298	+3.862	.008	.005	3	2
SKIN	IFNG →	+0.016	+4.437	<.001	.004	3	2
CNS	CLEC4E →	+0.111	+4.169	<.001	.008	3	1
CNS	MC2R →	+0.004	+4.754	<.001	.005	3	1
CNS	OR2W1 →	+0.030	+5.357	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

UGT2B11 by SCIN expression — CNS

Explore this box plot interactively →