SCG3

Across TCGA cell cohorts, SCG3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SCG3-associated genes across cancer lineages are CST9, OR11H6, and KRT77. Each is linked with SCG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCG3-to-partner and partner-to-SCG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST9 grouped by SCG3-low versus SCG3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCG3→partner) and Y-score (partner→SCG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CST9 →	+0.035	+4.981	<.001	.008	3	1
CNS	OR11H6 →	+0.035	+5.321	<.001	.005	3	1
CNS	KRT77 →	+0.027	+4.981	.007	.008	3	1
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1
LARGE_INTESTINE	SPATA8 →	+0.275	+4.347	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CST9 by SCG3 expression — CNS

Explore this box plot interactively →