SCG3

Across TCGA pan-cancer cohorts, SCG3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SCG3 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SCG3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCG3 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCEC show a favorable association.

UVM, LGG, and UCEC are the cancer types where SCG3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.431	0.852	<.001	96	view →
LGG	DFS	Median	All	0.811	0.660	<.001	53	view →
UCEC	DFS	Median	IV	0.833	0.553	.009	36	view →
MESO	OS	Quartile	IV	0.319	0.850	.011	29	view →
PAAD	DFS	Tertile	All	0.437	0.185	.002	23	view →
KIRP	OS	Tertile	All	0.811	0.928	.005	16	view →
LUSC	DFS	Median	II,III,IV	0.632	0.779	.009	15	view →
SCLC	DFS	Median	All	0.532	0.701	.007	11	view →
THYM	DFS	Tertile	III,IV	0.362	0.869	.035	9	view →
BLCA	DFS	Median	All	0.403	0.566	.023	8	view →
UCS	OS	Quartile	All	0.496	0.831	.019	8	view →
KIRC	DFS	Tertile	II,III,IV	0.834	0.624	.030	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SCG3–UVM (DFS)

Open the UVM breakdown →