SCG2

Across TCGA patient cohorts, SCG2 mutation is significantly associated with the RNA expression of many other genes, with 4,184 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCG2-associated genes across cancer lineages are NF1P10, DDHD2, and SUMO2P7. Each is linked with SCG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SCG2-to-partner and partner-to-SCG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF1P10 grouped by SCG2-low versus SCG2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCG2→partner) and Y-score (partner→SCG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NF1P10 →	+0.382	+5.569	<.001	.002	3	4
LUAD	DDHD2 →	+0.704	+3.205	<.001	.009	3	4
UCEC	SUMO2P7 →	+0.218	+1.784	.004	<.001	3	4
COAD	ATP5F1A →	+0.629	+3.362	<.001	.005	3	3
UCEC	SAR1B →	+0.434	+4.002	<.001	<.001	3	3
UCEC	ZKSCAN2 →	+0.355	+2.295	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,184 associations by consensus.

NF1P10 by SCG2 expression — CESC

Explore this box plot interactively →