SCG2

Across TCGA pan-cancer cohorts, SCG2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SCG2 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SCG2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SCG2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and ACC show a favorable association.

KIRP, BLCA, and CESC are the cancer types where SCG2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.634	0.886	<.001	110	view →
BLCA	OS	Tertile	All	0.523	0.720	<.001	108	view →
CESC	OS	Quartile	III,IV	0.423	0.877	.002	78	view →
STAD	DFS	Tertile	All	0.566	0.822	.003	64	view →
MESO	OS	Tertile	II,III,IV	0.265	0.527	.001	61	view →
LUAD	OS	Median	III,IV	0.316	0.669	<.001	52	view →
OV	DFS	Tertile	II,III,IV	0.478	0.614	.001	50	view →
PAAD	DFS	Median	All	0.379	0.179	<.001	43	view →
ACC	DFS	Tertile	All	0.764	0.387	<.001	42	view →
COAD	DFS	Tertile	All	0.715	0.832	.001	40	view →
UVM	OS	Median	III,IV	0.246	0.836	.003	35	view →
UCEC	OS	Quartile	All	0.871	0.949	.006	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SCG2–KIRP (OS)

Open the KIRP breakdown →