SCG2

Across TCGA pan-cancer cohorts, SCG2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SCG2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SCG2 RNA is repressed in tumor relative to normal tissue. In most cancer types SCG2 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where SCG2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCG2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−2.227	<.001	11	view →
KIRC	Male	IV	+1.718	<.001	11	view →
HNSC	All	III,IV	+1.128	<.001	9	view →
LIHC	All	All	+0.410	<.001	8	view →
KIRP	All	All	+1.152	<.001	7	view →
BRCA	All	III,IV	+1.303	<.001	6	view →
KICH	All	All	−0.384	.003	5	view →
LUSC	Female	All	+1.196	.001	4	view →
READ	Female	All	−3.290	<.001	3	view →
BLCA	All	All	+0.930	.017	3	view →
CHOL	All	All	+0.813	<.001	3	view →
STAD	Female	III,IV	−2.550	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SCG2–COAD

Open the COAD breakdown →