SCG2

Across TCGA patient cohorts, SCG2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCG2-associated genes across cancer lineages are Mre11, ASNS, and EGFR_pY1068. Each is linked with SCG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SCG2-to-partner and partner-to-SCG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mre11 grouped by SCG2-low versus SCG2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCG2→partner) and Y-score (partner→SCG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Mre11 →	+0.136	+3.330	.014	.005	3	4
UCEC	ASNS →	+0.311	+2.321	.015	.033	3	3
UCEC	EGFR_pY1068 →	-0.323	-2.874	<.001	<.001	3	2
UCEC	GATA6 →	-0.133	-1.655	.014	.011	3	2
UCEC	INPP4B →	-0.252	-2.459	.027	.018	3	2
UCEC	mTOR_pS2448 →	-0.134	-1.787	.010	.026	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Mre11 by SCG2 expression — COAD

Explore this box plot interactively →