SCG2

Across TCGA cell cohorts, SCG2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SCG2-associated genes across cancer lineages are CLEC4E, OR13D1, and USP17L17. Each is linked with SCG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCG2-to-partner and partner-to-SCG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC4E grouped by SCG2-low versus SCG2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCG2→partner) and Y-score (partner→SCG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CLEC4E →	+0.091	+3.347	<.001	.005	3	1
SKIN	OR13D1 →	+0.021	+3.345	<.001	.007	3	1
SKIN	USP17L17 →	+0.006	+4.022	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR10Q1 →	+0.073	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.017	+4.662	<.001	.005	3	1
BLOOD_Leukemia	PRRG3 →	+0.012	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

CLEC4E by SCG2 expression — SKIN

Explore this box plot interactively →