SCARNA21B

Across TCGA patient cohorts, SCARNA21B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,902 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SCARNA21B-associated GO terms across cancer lineages are Signal transduction in response to DNA damage, RISC complex assembly, and Regulation of proteasomal ubiquitin-dependent protein catabolic process. Each is linked with SCARNA21B in more than 13 cancer types. Because this analysis shows association rather than direction, both SCARNA21B-to-partner and partner-to-SCARNA21B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Signal transduction in response to DNA damage grouped by SCARNA21B-low versus SCARNA21B-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARNA21B→partner) and Y-score (partner→SCARNA21B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Signal transduction in response to DNA damage →	+0.058	+0.314	.001	.003	3	14
ESCA	RISC complex assembly →	+0.062	+0.409	<.001	<.001	3	14
STAD	Regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.045	+0.183	<.001	<.001	3	14
ESCA	Sex-chromosome dosage compensation →	+0.072	+0.283	<.001	.004	3	14
ESCA	Nuclear-transcribed mRNA catabolic process →	+0.067	+0.352	<.001	<.001	3	14
ESCA	Telomere maintenance via telomere lengthening →	+0.052	+0.331	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,902 associations by consensus.

Signal transduction in response to DNA damage by SCARNA21B expression — ESCA

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